Review
doi: 10.1007/978-3-642-81265-1_14.
Regulation of mouse mammary tumor virus gene expression by glucocorticoid hormones
- PMID: 226870
- DOI: 10.1007/978-3-642-81265-1_14
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Review
Regulation of mouse mammary tumor virus gene expression by glucocorticoid hormones
Monogr Endocrinol.
1979.
Abstract
Several laboratories have documented that glucocorticoid hormones markedly stimulate the expression of mouse mammary tumor virus genes in a variety of mouse mammary tumor cells and in infected heterologous cells. The effect of the hormone appears to be a rapid and specific augmentation of the synthesis of viral RNA, mediated by interaction with glucocorticoid receptor proteins. The availability of virus-specific reagents and recent developments in the molecular biology of RNA tumor viruses now permit a highly refined analysis of hormonal regulation in this experimental system.
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