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Case Reports
. 2011 Aug 17:2011:bcr0320114007.
doi: 10.1136/bcr.03.2011.4007.

Ten-year follow-up after autologous stem cell transplantation of a patient with immunoglobulin light-chain (AL) amyloidosis with deposits in the heart, liver and gastrointestinal tract

Marit Mejhert  1 , Robert Hast, Benngt Sandstedt, Izabella Janczewska
Affiliations
Case Reports

Ten-year follow-up after autologous stem cell transplantation of a patient with immunoglobulin light-chain (AL) amyloidosis with deposits in the heart, liver and gastrointestinal tract

Marit Mejhert et al. BMJ Case Rep. .

Abstract

The prognosis in amyloid light chain (AL)-amyloidosis and multiorgan involvement is poor, with a high-treatment-related mortality after high-dose melphalan and autologous stem cell transplantation (HDM/SCT). Some patients, however, might benefit from the therapy. We report a case of cardiac AL-amyloidosis with multiorgan involvement where the progressive cardiomyopathy was halted after successful treatment with HDM/SCT in 2001. The patient is in an excellent cardiac condition with a good quality of life, receiving treatment with angiotensinogen receptor blockers and a flexible diuretics regimen at follow-up after 10 years.

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Conflict of interest statement

Competing interests None.

Figures

Figure 1
Figure 1
Echocardiografic short axis (A), and parasternal view (B), showing left ventricular wall hypertrophy.
Figure 2
Figure 2
Myocardial biopsy with amyloid (red) deposits. Congo red stain ×250.
See this image and copyright information in PMC

References

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