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Editorial
. 2012 Jul;60(1):22-4.
doi: 10.1161/HYPERTENSIONAHA.112.195628. Epub 2012 Jun 11.

Breathe, breathe in the air: the ins and outs of hypoxia take their toll

Frank M Faraci
Editorial

Breathe, breathe in the air: the ins and outs of hypoxia take their toll

Frank M Faraci. Hypertension. 2012 Jul.
No abstract available

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Figures

Figure
Figure
Cerebrovascular effects of intermittent hypoxia. In response chronic intermittent hypoxia, increased production of endothelin-1 (ET-1) by endothelin-converting enzyme (ECE) activates ETA receptors (ETA-R) resulting in oxidative stress. ET-1 or oxidative stress may also activate components of the inflammatory response. Key consequences of intermittent hypoxia for the vessel wall and mechanisms that regulate cerebral blood flow are shown on the bottom. Nox2 = Nox2 component of NADPH oxidase; O2− = superoxide anion; PiO2 = inspired PO2; NVC = neurovascular coupling. See text for additional details.
See this image and copyright information in PMC

Comment on

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