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. 1990 Nov;19(5):416-22.
doi: 10.2165/00003088-199019050-00005.

Influence of age on the pharmacokinetics of alfentanil. Gender dependence

H J Lemmens  1 , A G Burm, P J Hennis, M P Gladines, J G Bovill
Affiliations

Influence of age on the pharmacokinetics of alfentanil. Gender dependence

H J Lemmens et al. Clin Pharmacokinet. 1990 Nov.

Abstract

Studies on the effects of age on the pharmacokinetics of alfentanil are inconclusive. A possible factor in explaining the differences between various studies could be the effect of gender. The authors studied the effects of age on the pharmacokinetics of alfentanil in female (n = 21) and male (n = 15) patients undergoing lower abdominal surgery under nitrous oxide alfentanil anaesthesia. There was a significant negative correlation (r = -0.79, p less than 0.001) between plasma alfentanil clearance (CL) and age in women (less than 50y, median CL 24.84 L/h; greater than 50y, median CL 14.52 L/h), but not in men (less than 50y, median CL 19.44 L/h; greater than 50y, median CL 16.2 L/h). The conclusion is drawn that the effects of age on the pharmacokinetics of alfentanil are gender-dependent.

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Comment in

  • Sex, age and alfentanil pharmacokinetics.
    Rubio A, Cox C. Rubio A, et al. Clin Pharmacokinet. 1991 Jul;21(1):81-2. doi: 10.2165/00003088-199121010-00006. Clin Pharmacokinet. 1991. PMID: 1914343 No abstract available.

References

    1. Anesthesiology. 1987 Jan;66(1):3-12 - PubMed
    1. Clin Pharmacol Ther. 1989 Jul;46(1):99-102 - PubMed
    1. Anesthesiology. 1984 Jul;61(1):27-35 - PubMed
    1. Clin Pharmacol Ther. 1984 Aug;36(2):239-43 - PubMed
    1. Anesthesiology. 1988 Jun;68(6):851-61 - PubMed

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