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Case Reports
. 2012 Jun 7;18(21):2727-9.
doi: 10.3748/wjg.v18.i21.2727.

A pediatric non-protein losing Menetrier's disease successfully treated with octreotide long acting release

Giovanni Di Nardo  1 , Salvatore Oliva, Marina Aloi, Federica Ferrari, Simone Frediani, Adriana Marcheggiano, Salvatore Cucchiara
Affiliations
Case Reports

A pediatric non-protein losing Menetrier's disease successfully treated with octreotide long acting release

Giovanni Di Nardo et al. World J Gastroenterol. .

Abstract

Pediatric Menetrier's disease (MD) is an uncommon, acute, self-limited hypertrophic gastropathy characterized by enlarged gastric folds associated with epithelial hyperplasia and usually accompanied by protein losing gastropathy. Gastric cytomegalovirus infection is found in one third of MD children and its treatment is often associated with remission. Diagnosis often requires full-thickness biopsy due to inability to detect typical histological findings with conventional endoscopic biopsy. We report an uncommon case of non self-limited pediatric MD needing endoscopic mucosal resection for diagnosis which was then successfully treated with octreotide long-acting release (LAR). To the best of our knowledge, this is the first pediatric MD case successfully treated with octreotide LAR. Our experience suggests octreotide LAR as treatment for refractory MD before gastrectomy.

Keywords: Children; Endoscopic mucosal resection; Menetrier’s disease; Octreotide.

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Figures

Figure 1
Figure 1
Endoscopic view of markedly thickened gastric folds, with overlying erosions and exudates involving fundus (A) and corpus (B).
Figure 2
Figure 2
Histopathology from endoscopic mucosal resection (HE staining; A: 40×, B: 20×) shows elongated, tortuous and cystically dilated foveolar glands, discontinuous atrophy of gastric glands and significant reduction of parietal cells.
See this image and copyright information in PMC

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