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. 2012:2012:418679.
doi: 10.1155/2012/418679. Epub 2012 May 30.

Plectranthus amboinicus and Centella asiatica Cream for the Treatment of Diabetic Foot Ulcers

Yuan-Sung Kuo  1 , Hsiung-Fei Chien, William Lu
Affiliations

Plectranthus amboinicus and Centella asiatica Cream for the Treatment of Diabetic Foot Ulcers

Yuan-Sung Kuo et al. Evid Based Complement Alternat Med. 2012.

Abstract

Effects of a topical cream containing P. amboinicus (Lour.) Spreng. (Lamiaceae) and C. asiatica (L.) Urban (Umbelliferae) were evaluated and compared to effects of hydrocolloid fiber wound dressing for diabetic foot ulcers. A single-center, randomized, controlled, open-label study was conducted. Twenty-four type 1 or type 2 diabetes patients aged 20 years or older with Wagner grade 3 foot ulcers postsurgical debridement were enrolled between October 2008 and December 2009. Twelve randomly assigned patients were treated with WH-1 cream containing P. amboinicus and C. asiatica twice daily for two weeks. Another 12 patients were treated with hydrocolloid fiber dressings changed at 7 days or when clinically indicated. Wound condition and safety were assessed at days 7 and 14 and results were compared between groups. No statistically significant differences were seen in percent changes in wound size at 7- and 14-day assessments of WH-1 cream and hydrocolloid dressing groups. A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9%) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance. For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness.

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Figures

Figure 1
Figure 1
Patients' flow chart.
Figure 2
Figure 2
Changes of wound size.
Figure 3
Figure 3
The improvement in wound size and Wagner grades of three patients in the WH-1 cream group. (a) Before WH-1 cream treatment, (b) the 14th day after treatment.
See this image and copyright information in PMC

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