Review
doi: 10.3109/09687688.2012.693211.
Epub 2012 Jun 14.
Structure, regulation and cellular functions of Rab geranylgeranyl transferase and its cellular partner Rab Escort Protein
Affiliations
- PMID: 22694141
- DOI: 10.3109/09687688.2012.693211
Item in Clipboard
Review
Structure, regulation and cellular functions of Rab geranylgeranyl transferase and its cellular partner Rab Escort Protein
Mol Membr Biol.
2012 Nov.
Free article
Abstract
Rab geranylgeranyl transferase is an enzyme responsible for double geranylgeranylation of Rab proteins in all eukaryotic cells. In the present article we would like to focus on new findings concerning the holoenzyme structure and mechanism of catalytic activity, its mode of regulation and consequences of RGGT deficiency in different eucaryotic model organisms and patients.
Similar articles
-
Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease.FEBS Lett. 2001 Jun 8;498(2-3):197-200. doi: 10.1016/s0014-5793(01)02483-8. FEBS Lett. 2001. PMID: 11412856 Review.
-
Analysis and preparation of stable complexes between Rab GTPases, Rab escort protein, and Rab geranylgeranyl transferase.Methods Mol Biol. 2002;189:157-65. doi: 10.1385/1-59259-281-3:157. Methods Mol Biol. 2002. PMID: 12094584 No abstract available.
-
Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases.J Lipid Res. 2006 Mar;47(3):467-75. doi: 10.1194/jlr.R500017-JLR200. Epub 2006 Jan 9. J Lipid Res. 2006. PMID: 16401880 Review.
-
Characterization of the ternary complex between Rab7, REP-1 and Rab geranylgeranyl transferase.Eur J Biochem. 1999 Oct 1;265(1):160-70. doi: 10.1046/j.1432-1327.1999.00699.x. Eur J Biochem. 1999. PMID: 10491170
-
Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate.Biochem J. 2008 Oct 1;415(1):67-75. doi: 10.1042/BJ20080662. Biochem J. 2008. PMID: 18532927
Cited by
-
An EHBP-1-SID-3-DYN-1 axis promotes membranous tubule fission during endocytic recycling.PLoS Genet. 2020 May 8;16(5):e1008763. doi: 10.1371/journal.pgen.1008763. eCollection 2020 May. PLoS Genet. 2020. PMID: 32384077 Free PMC article.
-
Structural basis of membrane trafficking by Rab family small G protein.Int J Mol Sci. 2013 Apr 25;14(5):8912-23. doi: 10.3390/ijms14058912. Int J Mol Sci. 2013. PMID: 23698755 Free PMC article. Review.
-
Impact of C-terminal truncations in the Arabidopsis Rab escort protein (REP) on REP-Rab interaction and plant fertility.Plant J. 2021 Dec;108(5):1400-1421. doi: 10.1111/tpj.15519. Epub 2021 Oct 16. Plant J. 2021. PMID: 34592024 Free PMC article.
-
All about that fat: Lipid modification of proteins in Cryptococcus neoformans.J Microbiol. 2016 Mar;54(3):212-22. doi: 10.1007/s12275-016-5626-6. Epub 2016 Feb 27. J Microbiol. 2016. PMID: 26920881 Free PMC article. Review.
-
PTRN-1/CAMSAP promotes CYK-1/formin-dependent actin polymerization during endocytic recycling.EMBO J. 2018 May 2;37(9):e98556. doi: 10.15252/embj.201798556. Epub 2018 Mar 22. EMBO J. 2018. PMID: 29567645 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
