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. 2012 Jul 16;51(29):7203-7.
doi: 10.1002/anie.201201390. Epub 2012 Jun 13.

Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment

So Jin Lee  1 , Myung Sook Huh, Seung Young Lee, Solki Min, Seulki Lee, Heebeom Koo, Jun-Uk Chu, Kyung Eun Lee, Hyesung Jeon, Yongseok Choi, Kuiwon Choi, Youngro Byun, Seo Young Jeong, Kinam Park, Kwangmeyung Kim, Ick Chan Kwon
Affiliations

Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment

So Jin Lee et al. Angew Chem Int Ed Engl. .

Erratum in

  • Angew Chem Int Ed Engl. 2012 Nov 19;51(47):11661

Abstract

The condensed version: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking (see scheme). This poly-siRNA/glycol chitosan nanoparticles (psi-TGC) provided sufficient in vivo stability for systemic delivery of siRNAs. Knockdown of tumor proteins by psi-TGC resulted in a reduction in tumor size and vascularization.

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