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Review
. 2012 Apr-Jun;25(2):355-63.
doi: 10.1177/039463201202500205.

Endothelial cells, cholesterol, cytokines, and aging

S Tetè, D Tripodi, M Rosati, F Conti, G Maccauro, A Saggini, V Salini, E Cianchetti, A Caraffa, P Antinolfi, E Toniato, M L Castellani, F Pandolfi, S Frydas, P Conti, T C Theoharides
Review

Endothelial cells, cholesterol, cytokines, and aging

S Tetè et al. Int J Immunopathol Pharmacol. 2012 Apr-Jun.

Abstract

It has been reported that high levels of cholesterol and triglycerides are associated with increased risk of developing atherosclerosis and shorter life. In fact, vascular endothelial dysfunction occurs during the human aging process. Accumulation of lipids in vascular endothelium activates leukocytes to produce cytokines and chemokines which recruit macrophages. On the other hand, macrophages augment inflammatory response and secrete vascular endothelial growth factor, a key cytokine that mediates angiogenesis and inflammatory response. In addition, hyperlipidaemia is one of the main risk factors for aging, hypertension and diabetes. Here, we review the interrelationship between endothelial cells, high level of cholesterol, and aging.

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