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. 2012 Jul 6;14(13):3352-5.
doi: 10.1021/ol3013342. Epub 2012 Jun 14.

Nickel-catalyzed reductive coupling of aryl halides with secondary alkyl bromides and allylic acetate

Shulin Wang  1 , Qun Qian, Hegui Gong
Affiliations

Nickel-catalyzed reductive coupling of aryl halides with secondary alkyl bromides and allylic acetate

Shulin Wang et al. Org Lett. .

Abstract

A room-temperature Ni-catalyzed reductive method for the coupling of aryl bromides with secondary alkyl bromides has been developed, providing C(sp(2))-C(sp(3)) products in good to excellent yields. Slight modification of this protocol allows efficient coupling of activated aryl chlorides with cyclohexyl bromide and aryl bromides with allylic acetate.

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