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. 2012 Jun 12;21(6):715-6.
doi: 10.1016/j.ccr.2012.05.029.

Silencing the killers: paracrine immune suppression in pancreatic cancer

Adrienne D Cox  1 , Kenneth P Olive
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Silencing the killers: paracrine immune suppression in pancreatic cancer

Adrienne D Cox et al. Cancer Cell. .
Free article

Abstract

Pancreatic cancers are characterized by high levels of inflammatory cells and profound immune suppression. In this issue of Cancer Cell, Bayne et al. and Pylayeva-Gupta et al. show that KRAS-driven, tumor cell-secreted GM-CSF recruits myeloid-derived suppressor cells to the stroma to abrogate tumor cell immune clearance by killer T lymphocytes.

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