A big step for SIRT7, one giant leap for Sirtuins… in cancer
- PMID: 22698398
- DOI: 10.1016/j.ccr.2012.05.028
A big step for SIRT7, one giant leap for Sirtuins… in cancer
Erratum in
- Cancer Cell. 2012 Aug 14;22(2):278
Abstract
Recently reporting in Nature, Barber et al. demonstrated that SIRT7 maintains critical features that define cancer cells by removing the acetylation mark on lysine 18 of histone H3. Interestingly, hypoacetylation of H3K18 has been described as a general marker of tumor prognosis and oncoviral transformation.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation.Nature. 2012 Jul 5;487(7405):114-8. doi: 10.1038/nature11043. Nature. 2012. PMID: 22722849 Free PMC article.
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