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. 2012 Jun 12;21(6):719-21.
doi: 10.1016/j.ccr.2012.05.028.

A big step for SIRT7, one giant leap for Sirtuins… in cancer

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A big step for SIRT7, one giant leap for Sirtuins… in cancer

Paloma Martínez-Redondo et al. Cancer Cell. .
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Erratum in

  • Cancer Cell. 2012 Aug 14;22(2):278

Abstract

Recently reporting in Nature, Barber et al. demonstrated that SIRT7 maintains critical features that define cancer cells by removing the acetylation mark on lysine 18 of histone H3. Interestingly, hypoacetylation of H3K18 has been described as a general marker of tumor prognosis and oncoviral transformation.

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