Oxygen is the key factor associated with the difference between in vivo and in vitro effects of antioxidants
- PMID: 22699512
- PMCID: PMC3409738
- DOI: 10.1073/pnas.1205916109
Oxygen is the key factor associated with the difference between in vivo and in vitro effects of antioxidants
Conflict of interest statement
The author declares no conflict of interest.
Comment on
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5423-8. doi: 10.1073/pnas.1114278109. Epub 2012 Mar 19. Proc Natl Acad Sci U S A. 2012. PMID: 22431602 Free PMC article.
References
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- Wada Y, et al. Lipid accumulation in smooth muscle cells under LDL loading is independent of LDL receptor pathway and enhanced by hypoxic conditions. Arterioscler Thromb Vasc Biol. 2002;22:1712–1719. - PubMed
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