Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2011 Mar 29:2011:bcr0120113755.
doi: 10.1136/bcr.01.2011.3755.

Severe hyponatraemia during sepsis and marijuana addiction

Concetta Catalano  1 , Sidy Seck, Giuseppe Enia
Affiliations
Case Reports

Severe hyponatraemia during sepsis and marijuana addiction

Concetta Catalano et al. BMJ Case Rep. .

Abstract

The authors report a 29-year-old kidney transplant patient who presented, four episodes of severe hyponatraemia associated with sepsis from 2006 to 2010. He was a long-term user of marijuana. The association between severe recurrent hyponatraemia during sepsis and marijuana addiction might not be casual, since experimental data show that vasopressin release induced by sepsis is modulated by the endocannabinoid system.

PubMed Disclaimer

Conflict of interest statement

Competing interests None.

References

    1. Campbell GA, Rosner MH. The agony of ecstasy: MDMA (3,4-Methylenedioxymethamphetamine) and the kidney. Clin J Am Soc Nephrol 2008;3:1852–60 - PubMed
    1. De Laurentiis A, Fernández Solari J, Mohn C, et al. Endocannabinoid system participates in neuroendocrine control of homeostasis. Neuroimmunomodulation 2010;17:153–6 - PubMed
    1. Sofia RD, Knobloch LC, Harakal JJ, et al. Comparative diuretic activity of delta9-tetrahydrocannabinol, cannabidiol, cannabinol and hydrochlorothiazide in the rat. Arch Int Pharmacodyn Ther 1977;225:77–87 - PubMed
    1. Tyrey L, Murphy LL. Inhibition of suckling-induced milk ejections in the lactating rat by delta 9-tetrahydrocannabinol. Endocrinology 1988;123:469–72 - PubMed
    1. De Laurentiis A, Fernandez-Solari J, Mohn C, et al. The hypothalamic endocannabinoid system participates in the secretion of oxytocin and tumor necrosis factor-alpha induced by lipopolysaccharide. J Neuroimmunol 2010;221:32–41 - PubMed

Publication types