Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2011 Apr 15:2011:bcr0120113692.
doi: 10.1136/bcr.01.2011.3692.

Pyrexia of unknown origin and pulmonary fibrosis as a presentation of MPO-ANCA associated vasculitis

O Shields  1 , A Shah, B Mann
Affiliations
Case Reports

Pyrexia of unknown origin and pulmonary fibrosis as a presentation of MPO-ANCA associated vasculitis

O Shields et al. BMJ Case Rep. .

Abstract

The authors report the case of a 72-year-old man presenting with chronic dyspnoea and pyrexia of unknown origin (PUO). After extensive investigation, he was found to have pulmonary fibrosis with usual interstitial pneumonia pattern on high-resolution CT imaging and positive myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA) with no infectious cause or other evidence of vasculitis organ involvement. His pyrexia and symptoms settled with oral systemic corticosteroid treatment. To the authors' knowledge this is the first case of MPO-ANCA positive vasculitis presenting as PUO and pulmonary fibrosis alone. The authors review the recent literature regarding the association of pulmonary fibrosis with ANCA-positive vasculitides with regards to pathogenesis, prognosis and treatment.

PubMed Disclaimer

Conflict of interest statement

Competing interests None.

Figures

Figure 1
Figure 1
High-resolution CT scan showing classical features of usual interstitial pneumonitis with subpleural basal interlobular septal thickening and early honeycombing.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Guillevin L, Durand-Gasselin B, Cevallos R, et al. Microscopic polyangiitis: clinical and laboratory findings in eighty-five patients. Arthritis Rheum 1999;42:421–30 - PubMed
    1. Ando Y, Okada F, Matsumoto S, et al. Thoracic manifestation of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-related disease. CT findings in 51 patients. J Comput Assist Tomogr 2004;28:710–16 - PubMed
    1. Hervier B, Pagnoux C, Agard C, et al. Pulmonary fibrosis associated with ANCA-positive vasculitides. Retrospective study of 12 cases and review of the literature. Ann Rheum Dis 2009;68:404–7 - PubMed
    1. Akar H, Ozbasli-Levi C, Senturk T, et al. MPO-ANCA-associated small vessel vasculitis presenting as fever of unknown origin. Report of one case. Nephron 2002;92:673–5 - PubMed
    1. Ohnuma K, Hosono O, Katayose T, et al. Microscopic polyangiitis initiated with liver dysfunction, calf pain and fever of unknown origin. Rheumatol Int 2010;30:1651–6 - PubMed

Publication types

MeSH terms