Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 May;44(3):412-4.
doi: 10.4103/0253-7613.96351.

Allopurinol-induced DRESS syndrome

Selcuk Yaylacı  1 , Mustafa Volkan Demir, Tayfun Temiz, Ali Tamer, Mustafa Ihsan Uslan
Affiliations

Allopurinol-induced DRESS syndrome

Selcuk Yaylacı et al. Indian J Pharmacol. 2012 May.

Abstract

A 70-year-old man was admitted to our clinic with complaints of fever, jaundice, dyspnea, and generalized rash after 3 months of allopurinol treatment for gout. On physical examination, he was found to have fever (38.5°C), jaundice, and generalized maculopapular rash. Leukocytosis, eosinophilia, elevation of liver enzymes, and hyperbilirubinemia were detected in his blood analysis. Skin biopsy was consistent with drug-induced hypersensitivity. He was diagnosed as Drug Rash with Eosinophilia and Systemic Symptoms (DRESS). Allopurinol treatment was stopped and steroid treatment was launched. At day 24 of admission, the patient died because of multiple organ failure.

Keywords: Allopurinol; DRESS syndrome; gout; skin biopsy.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Rash after 3 months of allopurinol treatment for gout
See this image and copyright information in PMC

References

    1. Terkeltaub RA. Clinical practice.Gout. N Engl J Med. 2003;349:1647–55. - PubMed
    1. Kumari R, Timshina DK, Thappa DM. Drug hypersensitivity syndrome. Indian J Dermatol Venereol Leprol. 2011;77:7–15. - PubMed
    1. Tas S, Simonart T. Management of drug rash with eosinophilia and systemic symptoms (DRESS syndrome): An update. Dermatology. 2003;206:353–6. - PubMed
    1. Lee HY, Ariyasinghe JT, Thirumoorthy T. Allopurinol hypersensitivity syndrome: A preventable severe cutaneous adverse reaction? Singapore Med J. 2008;49:384–7. - PubMed
    1. Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L, et al. The DRESS syndrome: A literature review. Am J Med. 2011;124:588–97. - PubMed