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. 2012;7(6):e38476.
doi: 10.1371/journal.pone.0038476. Epub 2012 Jun 6.

Defining and detecting crossover-interference mutants in yeast

Frank Stahl  1
Affiliations

Defining and detecting crossover-interference mutants in yeast

Frank Stahl. PLoS One. 2012.

Abstract

The analysis of crossover interference in many creatures is complicated by the presence of two kinds of crossovers, interfering and noninterfering. In such creatures, the values of the traditional indicators of interference are subject not only to the strength of interference but also to the relative frequencies of crossing over contributed by the two kinds. We formalize the relationship among these variables and illustrate the possibilities and limitations of classical interference analysis with meiotic tetrad data from wild-type Saccharomyces cerevisiae and from mlh1 and ndj1 mutants.

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Conflict of interest statement

Competing Interests: The author has declared that no competing interests exist.

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