Cooking up tolerance: has a new recipe been created?

Editorial

L S Kean et al. Am J Transplant. 2012 Jul.

. 2012 Jul;12(7):1667-9.

doi: 10.1111/j.1600-6143.2012.04154.x. Epub 2012 Jun 15.

No abstract available

Conflict of interest statement

Disclosure

The authors of this manuscript have no conflicts of interest to disclose as described by the American Journal of Transplantation.

Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation.
Leventhal J, Abecassis M, Miller J, Gallon L, Ravindra K, Tollerud DJ, King B, Elliott MJ, Herzig G, Herzig R, Ildstad ST. Leventhal J, et al. Sci Transl Med. 2012 Mar 7;4(124):124ra28. doi: 10.1126/scitranslmed.3003509. Sci Transl Med. 2012. PMID: 22399264 Free PMC article.

1. Leventhal J, Abecassis M, Miller J, et al. Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation. Sci Transl Med. 2012;4:124–128. - PMC - PubMed
1. Sayegh MH, Fine NA, Smith JL, Rennke HG, Milford EL, Tilney NL. Immunologic tolerance to renal allografts after bone marrow transplants from the same donors. Ann Intern Med. 1991;114:954–955. - PubMed
1. Reisner Y, Hagin D, Martelli MF. Haploidentical hematopoietic transplantation: Current status and future perspectives. Blood. 2011;118:6006–6017. - PubMed
1. Di Ianni M, Falzetti F, Carotti A, et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood. 2011;117:3921–3928. - PubMed
1. Rachamim N, Gan J, Segall H, et al. Tolerance induction by “megadose” hematopoietic transplants: Donor-type human CD34 stem cells induce potent specific reduction of host anti-donor cytotoxic T lymphocyte precursors in mixed lymphocyte culture. Transplantation. 1998;65(10):1386–1393. - PubMed