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. 2010 Sep;1(1-2):7-11.
doi: 10.1007/s13148-010-0001-7. Epub 2010 May 8.

Challenge and promise: the role of miRNA for pathogenesis and progression of malignant melanoma

Salma Essa, N Denzer, U Mahlknecht, R Klein, E M Collnot, J Reichrath

Challenge and promise: the role of miRNA for pathogenesis and progression of malignant melanoma

Salma Essa et al. Clin Epigenetics. 2010 Sep.

Abstract

microRNAs are endogenous noncoding RNAs that are implicated in gene regulation. More recently, miRNAs have been shown to play a pivotal role in multiple cellular processes that interfere with tumorigenesis. Here we summarize the essential role of microRNAs for human cancer with special focus on malignant melanoma and the promising perspectives for cancer therapies.

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Figures

Fig. 1
Fig. 1
miRNA biogenesis: miRNAs originate in the nucleus as hairpin precursors and then are processed by the RNaseIII enzymes, Drosha and Dicer, to yield double-stranded RNA. One strand is selected to function as mature miRNA and loaded into the RISC, while another strand is degraded. Then miRNA binds imperfectly with its target mRNA in animal, whereas it binds with perfect complementarity in plants, resulting in mRNA translational repression
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