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Review
. 2012 Jun 14;10(6):690-697.
doi: 10.1016/j.stem.2012.05.006.

Hematopoietic stem cell heterogeneity takes center stage

Michael R Copley  1 , Philip A Beer  1 , Connie J Eaves  2
Affiliations
Free article
Review

Hematopoietic stem cell heterogeneity takes center stage

Michael R Copley et al. Cell Stem Cell. .
Free article

Abstract

Over the past 10 years, increasing evidence has accumulated that heterogeneity is a feature of hematopoietic stem cell (HSC) proliferation, self-renewal, and differentiation based on examination of these properties at a clonal level. The heterogeneous behavior of HSCs reflects the operation of a complex interplay of intrinsic and extrinsic variables. In this review, we discuss key findings from the last 5 years that reveal new insights into the mechanisms involved.

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