Review
doi: 10.1016/j.chom.2012.05.008.
An all-purpose antimalarial drug target
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- PMID: 22704614
- DOI: 10.1016/j.chom.2012.05.008
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Review
An all-purpose antimalarial drug target
Cell Host Microbe.
.
Free article
Abstract
The recent re-emphasis on malaria eradication has made developing drugs that block transmission and terminate latent disease critical. Most drugs do not affect the liver stages-an ability that is crucial to the latter goal. Addressing this problem, Hoepfner et al. (2012) uncover the parasite's lysyl-tRNA synthetase as a druggable target.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin.Cell Host Microbe. 2012 Jun 14;11(6):654-63. doi: 10.1016/j.chom.2012.04.015. Cell Host Microbe. 2012. PMID: 22704625 Free PMC article.
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