Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Nov 30;206(4422):1081-3.
doi: 10.1126/science.227059.

A sign inversion mechanism for enzymatic supercoiling of DNA

P O Brown, N R Cozzarelli

A sign inversion mechanism for enzymatic supercoiling of DNA

P O Brown et al. Science. .

Abstract

Both the introduction and the removal of supertwists by DNA gyrase change the linking number of DNA in steps of two. This surprising finding provides strong evidence that gyrase acts by a mechanism, called sign inversion, whereby a positive supercoil is directly inverted into a negative one via a transient double-strand break.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources