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. 2012;3(9):441-4.
doi: 10.1016/j.ijscr.2012.05.008. Epub 2012 May 24.

Primary biliary tract melanoma: Report of a case and review of the literature

Nathaniel E Smith  1 , Janis M Taube, Tam M Warczynski, Kevin D Collier, Timothy M Pawlik
Affiliations

Primary biliary tract melanoma: Report of a case and review of the literature

Nathaniel E Smith et al. Int J Surg Case Rep. 2012.

Abstract

Introduction: Primary melanoma of the bile duct is extremely rare with only nine cases of primary melanoma of the bile duct reported in the literature.

Presentation of case: A 55-year-old previously healthy gentleman developed increasing jaundice over several months and subsequently underwent an ERCP with stone extraction. Cytology brushings in an area of a distal stricture in the bile duct were concerning for cholangiocarcinoma. The patient was referred to our institution and underwent a pancreaticoduodenectomy. The surgical specimen showed a single 4.5cm polypoid lesion located in the bile duct. A diagnosis of melanoma was rendered after immunohistochemical studies on the tumor demonstrated positivity for melanoma markers. Follow-up of the patient with skin, ocular, and lymph node exams showed no evidence of melanoma. A PET scan 4 and 10 months post-surgery failed to reveal either a primary skin lesion or other sites of metastases.

Discussion: The vast majority of melanomas of the bile duct represent metastases from a cutaneous source and tend to present as multiple flat pigmented lesions. Conversely, cases of primary bile duct melanoma are characterized by a distinct gross morphology consisting of a solitary intraluminal polypoid lesion attached by a pedicle with no other identifiable primary lesion. Other supporting criteria include absence of other involved sites and presence of an in situ junctional component.

Conclusion: Given the clinical history, gross findings, and lack of a primary cutaneous site or other demonstrable metastases, this patient likely represents the tenth reported case of primary biliary tract melanoma.

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Figures

Fig. 1
Fig. 1
Cholangiogram from the ERCP depicting. (A) The area of obstruction (arrow) and (B) the subsequently placed endo-biliary stent (arrow).
Fig. 2
Fig. 2
Solitary intraluminal polypoid mass arising from the common bile duct.
Fig. 3
Fig. 3
Hematoxylin and eosin staining demonstrated sheets of cells with moderate amounts of eosinophilic cytoplasm and pleomorphic nuclei with nuclear inclusions and scattered mitotic figures (original magnification 160×).
Fig. 4
Fig. 4
Edge of lesion in relation to overlying bile duct. Multiple areas of the lesion showed cellular discohesion (hematoxylin–eosin, original magnification 64×).
See this image and copyright information in PMC

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