Antiretroviral therapy and cardiovascular risk
- PMID: 22707576
- PMCID: PMC3062864
- DOI: 10.1136/bcr.10.2010.3429
Antiretroviral therapy and cardiovascular risk
Abstract
The increase in the risk of myocardial infarction can be explained by antiretroviral-induced changes in conventional cardiovascular risk factors. Individual drugs within a drug class vary in their propensity to cause metabolic disturbances, and therefore, further studies are needed to determine the contribution of each drug to cardiovascular risk. A careful stratification of the cardiovascular risk and cardiovascular monitoring of HIV-infected individuals should be performed at baseline and at regular intervals during follow-up for this chronic medical condition. Standard primary and secondary prevention measures should be instituted in accordance with British Guidelines (Heart association, National Institute for Health and Clinical Excellence, etc for lipids, smoking and hypertension) Consideration of cardiovascular risk and drug-drug interactions when prescribing is crucial in the safe and optimum management of these patients. Careful communication between all care providers will help to avoid adverse outcomes.
Conflict of interest statement
References
-
- Mary-Krause M, Cotte L, Simon A, et al. ; Clinical Epidemiology Group from the French Hospital Database Increased risk of myocardial infarction with duration of protease inhibitor therapy in HIV-infected men. AIDS 2003;17:2479–86 - PubMed
-
- Friis-Møller N, Reiss P, Sabin CA, et al. ; DAD Study Group Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med 2007;356:1723–35 - PubMed
-
- Worm SW, Sabin C, Weber R, et al. Risk of myocardial infarction in patients with HIV infection exposed to specific individual antiretroviral drugs from the 3 major drug classes: the data collection on adverse events of anti-HIV drugs (D:A:D) study. J Infect Dis 2010;201:318–30 - PubMed
-
- Behrens GM, Reiss P. Abacavir and cardiovascular risk. Curr Opin Infect Dis 2010;23:9–14 - PubMed
-
- Hürlimann D, Weber R, Enseleit F, et al. [HIV infection, antiretroviral therapy, and endothelium]. Herz 2005;30:472–80 - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical