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Case Reports
. 2011 Feb 24:2011:bcr1120103550.
doi: 10.1136/bcr.11.2010.3550.

An unusual case of primary anaplastic large cell central nervous system lymphoma: an 8-year success story

Sindu Vivekanandan  1 , Peter Dickinson, Eric Bessell, Simon O'Connor
Affiliations
Case Reports

An unusual case of primary anaplastic large cell central nervous system lymphoma: an 8-year success story

Sindu Vivekanandan et al. BMJ Case Rep. .

Abstract

Primary central nervous system anaplastic large cell lymphoma (PCNS ALCL) is rare, with only three adult patients reported. We describe a patient with PCNS ALCL with the longest follow-up period so far reported. The patient was successfully treated with chemotherapy and radiotherapy. The patient is well, independent and in full-time employment and has no residual neurological deficit. He has normal mental status, has a full head of hair and has fathered a healthy child.

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Conflict of interest statement

Competing interests None.

Figures

Figure 1
Figure 1
400× H+E shows a tumour composed of sheets of large cytologically atypical lymphoid blast cells interspersed with frequent neutrophil polymorphs.
Figure 2
Figure 2
600× H+E highlights the abnormal morphology of the lymphoid population, which possess vesicular nuclei and prominent nucleoli, together with relatively abundant amphophilic cytoplasm.
Figure 3
Figure 3
The T cell antigen CD3 is strongly expressed by the atypical cells.
Figure 4
Figure 4
The anaplastic large cell lymphoma associated antigen CD30 is also strongly expressed.
See this image and copyright information in PMC

References

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