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. 2012 Sep;56(9):4948-50.
doi: 10.1128/AAC.05990-11. Epub 2012 Jun 18.

Azole preexposure affects the Aspergillus fumigatus population in patients

Alexandre Alanio  1 , Odile Cabaret, Emilie Sitterlé, Jean-Marc Costa, Sylvain Brisse, Catherine Cordonnier, Stéphane Bretagne
Affiliations

Azole preexposure affects the Aspergillus fumigatus population in patients

Alexandre Alanio et al. Antimicrob Agents Chemother. 2012 Sep.

Abstract

The relationship between the azole preexposure of 86 patients and the genotype, azole susceptibility, and cyp51A polymorphisms of 110 corresponding Aspergillus fumigatus isolates was explored. Isolates carrying serial polymorphisms (F46Y and M172V with or without N248T with or without D255E with or without E427K) had higher itraconazole MICs (P = 0.04), although <2 μg/ml using the EUCAST methodology, were associated with two genetic clusters (P < 0.001) and with voriconazole preexposure of patients (P = 0.016). Voriconazole preexposure influences the distribution of A. fumigatus isolates with selection of isolates carrying cyp51A polymorphisms and higher itraconazole MICs.

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