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Clinical Trial
. 1990 Nov;30(5):733-6.
doi: 10.1111/j.1365-2125.1990.tb03843.x.

The effect of cholestyramine and activated charcoal on glipizide absorption

K T Kivistö  1 , P J Neuvonen
Affiliations
Clinical Trial

The effect of cholestyramine and activated charcoal on glipizide absorption

K T Kivistö et al. Br J Clin Pharmacol. 1990 Nov.

Abstract

1. The interference of cholestyramine and activated charcoal with the absorption of glipizide was studied. 2. In a cross-over study comprising three phases, single doses of cholestyramine (8 g), activated charcoal (8 g) or water only were given to six healthy volunteers together with a single dose of glipizide. 3. The absorption of glipizide was moderately (29%, P less than 0.01) reduced by cholestyramine and greatly reduced (81%, P less than 0.01) by activated charcoal. 4. If cholestyramine and glipizide are used concomitantly, glipizide should be taken 1-2 h beforehand. In acute glipizide overdosage, activated charcoal can be used to reduce absorption.

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