Serum levels of soluble interleukin-2 receptor in pulmonary tuberculosis

Abstract

It is well known that the activation of cell mediated immunity has an important role in the pathogenesis of pulmonary tuberculosis and the production of the protective immunity against Mycobacterium tuberculosis. During the activation of T-cell by Interleukin-1 released from the macrophage, not only Interleukin-2 but also the soluble Interleukin-2 receptor (sIL-2R) molecule is released into the extracellular fluid. In vitro study reveals that the level of this sIL-2R is well correlated with the degree of activation of the T-cell. We therefore carried out this study to evaluate the significance of the serum IL-2R level in determining the disease activity of pulmonary tuberculosis. The level of sIL-2R was measured by sandwich ELISA method. The level of sIL-2R in 42 patients with bacteriologically -proven active pulmonary tuberculosis (29 far and moderately advanced pulmonary tuberculosis, age: 30.3 +/- 10.3 yrs; 13 minimal pulmonary tuberculosis, age: 34.4 +/- 15.3 yrs) was 1111 +/- 424 mu/ml, which was significantly higher than the normal control group (age: 31.0 +/- 9.9 yrs) (365 +/- 143 mu/ml) and inactive pulmonary tuberculosis group (age: 37.3 +/- 16.9 yrs) (465 +/- 131 mu/ml). But there was no significant difference between 29 patients with advanced pulmonary tuberculosis (1138 +/- 405 mu/ml) and 13 patients with minimal pulmonary tuberculosis (1051 +/- 474 mu/ml).(ABSTRACT TRUNCATED AT 250 WORDS)

Fig. 1.

Levels of serum soluble interleukin-2 receptor (sIL-2R) in patients and control groups. NC: Normal control: FA & MA TB: Far advanced and moderately advanced pulmonary tuberculosis: Min TB: Minimal pulmonary tuberculosis: Inac TB: Inactive pulmonary tuberculosis: OLD: Other lung diseases (pneumonia, bronchiectasis, cancer)

Fig. 2.

Serial observations of the serum sIL-2R levels in patients with active pulmonary tuberculosis during antituberculosis chemotherapy. Shaded area shows mean±2 SD of normal control group.