Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Jan;5(1):58-62.
doi: 10.3904/kjim.1990.5.1.58.

Urinary plasminogen activator activity in progressive renal failure

S Y Hong  1 , D H Yang
Affiliations

Urinary plasminogen activator activity in progressive renal failure

S Y Hong et al. Korean J Intern Med. 1990 Jan.

Abstract

The purpose of this study was to discover how functional nephrons produce the plasminogen activator as renal function progresses to renal failure. Urine Plasminogen activator (U-PA) activity was measured by the fibrin plate method in 73 patients with various degrees of renal function deterioration from various underlying diseases and in one healthy individual in order to evaluate the plasminogen activator activity of remnant nephrons. The plasminogen activator activity of the 12 consecutive urine samples from the healthy individual showed that is varied according to the time of day, but there was no circadian rhythm. The urine plasminogen activator activity correlated with the osmolality (r = 0.51, P less than 0.001) and creatinine (r = 0.56, P less than 0.001) of the urine, suggesting that it is concentrated at distal nephrons. The fractional sodium excretion rate (FeNa) increased abruptly when GFR decreased below 25 L/day. This pattern was very similar with the relation between total U-PA activity/GFR and GFR. The correlation between total U-PA activity and FeNa was not significant, but there was a significant direct correlation between total U-PA activity/GFR and FeNa (r = 0.775, P less than 0.0001). There was no relationship between the 24-hour urine protein and total U-PA activity or total U-PA activity/GFR.(ABSTRACT TRUNCATED AT 250 WORDS)

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Urine plasminogen activator activity of 12 consecutive urine samples during one day from a 42-year-old male subject.
Fig. 2.
Fig. 2.
The dependence of urine plasminogen activator activity on the urine osmolality and urine creatinine. Urine plasminogen activator activity of 12 consequential urine samples of a 42-year-old candidate during one day plotted against urine osmolality (mOsm/kg) and urine creatinine concentration (mg/dl).
Fig. 3.
Fig. 3.
The correlation between creatinine clearance and total fibrinolytic activity in urine (Fig. 3-a) and total urine plasminogen activator activity/GFR (Fig. 3-b). Fig. 3-c shows the correlation between GFR and FeNa in all patients who participated in this study
Fig. 4.
Fig. 4.
The correlation between FeNa (%) and total urine fibrinolytic activity (Fig. 4-a) and total urine plasminogen activator activity/GFR (Fig. 4-b).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Lesuk A, Terminiellol, Traver JH. Crystalline human urokinase: Some properties. Science. 1965;147:880. - PubMed
    1. White WF, Barlow GH, Mozen MM. The isolation and characterization of plasminogen activators (urokinase) from human urine. Biochemistry. 1966;5:2160. - PubMed
    1. Bergstein JM, Michael AF., Jr Cortical fibrinolytic activity in normal and diseased human kidneys. J Lab Clin Med. 1972;79701 - PubMed
    1. Bergstein JM, Michael AF., Jr Renal cortical fibrinolytic activity in the rabbit following one or two doses of endotoxin. Thromb Diath Haemorrh. 1973;29:27. - PubMed
    1. Bergstein JM, Hoyer JR, Michael AF., Jr Glomerular fibrinolytic activity following endotoxin-induced glomerular fibrin deposition in the pregnant rat. Am J Pathol. 1974;75:195. - PMC - PubMed