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Case Reports
. 2011 Feb 9:2011:bcr1120103474.
doi: 10.1136/bcr.11.2010.3474.

Primary spleen lymphoma associated with hepatitis C virus infection

Ricardo Cotta-Pereira  1 , Roberta Acar, Carlos Eduardo Brandão Mello, Antonio Carlos Iglesias, Carlos Alberto Basílio-de-Oliveira
Affiliations
Case Reports

Primary spleen lymphoma associated with hepatitis C virus infection

Ricardo Cotta-Pereira et al. BMJ Case Rep. .

Abstract

Lymphoproliferative disorders associated with hepatitis C virus (HCV) make up a heterogeneous group of diseases, including lymphomas. It was only recently that HCV was recognised as being a potential cause for the development of non-Hodgkin's lymphoma. The authors report a case of an older woman with chronic hepatitis C who developed primary spleen lymphoma. This case report points out the pathophysiological mechanisms of this disease and the importance of considering this disease in the differential diagnosis of patients with chronic HCV infection.

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Conflict of interest statement

Competing interests None.

Figures

Figure 1
Figure 1
Hypoecogenic splenic nodule, solid and heterogeneous, measuring 4.8×5.6 cm (see arrow).
Figure 2
Figure 2
CT of abdomen demonstrating spleen with augmented volume and large hypodense area (yellow arrow), in addition to an expansive formation of soft parts measuring approximately 3.3×3.2 cm at the largest axial diameters (blue arrow), located at the back of the liver left lobe.
Figure 3
Figure 3
Lobulated tumoral mass, whitish, extrapolating the organ limits and reaching the hilum.
Figure 4
Figure 4
Diffused non-Hodgkin's lymphoma with large cells showed by arrows.
Figure 5
Figure 5
Immunohistochemical study showing positiveness for CD 20 (see arrows).
See this image and copyright information in PMC

References

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