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. 2012 Jun 20:4:36.
doi: 10.1186/1758-3284-4-36.

Spinal metastasis in head and neck cancer

Gregory M Trilling  1 , Hyongyu Cho, Mohamed A Ugas, Samerah Saeed, Asia Katunda, Waseem Jerjes, Peter Giannoudis
Affiliations

Spinal metastasis in head and neck cancer

Gregory M Trilling et al. Head Neck Oncol. .

Expression of concern in

  • Comment: Head and Neck Oncology.
    BioMed Central. BioMed Central. BMC Med. 2014 Feb 5;12:24. doi: 10.1186/1741-7015-12-24. BMC Med. 2014. PMID: 24499430 Free PMC article. Review.

Abstract

Background: The incidence of head and neck cancer is relatively low in developed countries and highest in South East Asia. Notwithstanding advances in surgery and radiotherapy over the past several decades, the 5-year survival rate for head and neck cancer has stagnated and remains at 50-55%. This is due, in large part, to both regional and distant disease spread, including spinal metastasis. Spinal metastasis from head and neck cancer is rare, has a poor prognosis and can significantly impede end-stage quality of life; normally only palliative care is given.This study aims to conduct a systematic review of the evidence available on management of spinal metastasis from head and neck cancer and to use such evidence to draw up guiding principles in the management of the distant spread.

Methods: Systematic review of the electronic literature was conducted regarding the management of spinal metastasis of head and neck malignancies.

Results: Due to the exceptional rarity of head and neck cancers metastasizing to the spine, there is a paucity of good randomized controlled trials into the management of spinal metastasis. This review produced only 12 case studies/reports and 2 small retrospective cohort studies that lacked appropriate controls.

Conclusion: Management should aim to improve end-stage quality of life and maintain neurological function. This review has found that radiotherapy +/- medical adjuvant is considered the principle treatment of spinal metastasis of head and neck cancers.There is an absence of a definitive treatment protocol for head and neck cancer spinal metastasis. Our failure to find and cite high-quality scientific evidence only serves to stress the need for good quality research in this area.

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Figures

Figure 1
Figure 1
Research criteria.
Figure 2
Figure 2
Pathway of spread of head and neck cancer to bone – squamous cell carcinoma local and distant metastasis to bone. Adapted from Sano & Myers (2007) [42], Carter & Pittman (1980) [43], Yu et al. (2008) [35] & Yin and Pollock Claire (2005) [44].
Figure 3
Figure 3
Pathway of Investigations for bone metastasis from the oral cavity, oropharynx, laryngopharynx and hypopharynx. Adapted from Destombe et al. (2005) & Yu et al. (2008) [35].
Figure 4
Figure 4
Management pathway of spinal metastasis. Adapted from Preciado et al. (2002) [20].
See this image and copyright information in PMC

References

    1. Jerjes W, Upile T, Petrie A, Riskalla A, Hamdoon Z, Vourvachis M, Karavidas K, Jay A, Sandison A, Thomas GJ, Kalavrezos N, Hopper C. Clinicopathological parameters, recurrence, locoregional and distant metastasis in 115 T1-T2 oral squamous cell carcinoma patients. Head Neck Oncol. 2010;2:9. doi: 10.1186/1758-3284-2-9. - DOI - PMC - PubMed
    1. Saman DM. A review of the epidemiology of oral and pharyngeal carcinoma: update. Head Neck Oncol. 2012;4:1. doi: 10.1186/1758-3284-4-1. - DOI - PMC - PubMed
    1. Upile T, Jerjes W, Al-Khawalde M, Radhi H, Sudhoff H. Oral sex, cancer and death: sexually transmitted cancers. Head Neck Oncol. 2012;4(1):31. doi: 10.1186/1758-3284-4-31. - DOI - PMC - PubMed
    1. Lagha A, Chraiet N, Ayadi M, Krimi S, Allani B, Rifi H, Raies H, Mezlini A. Systemic therapy in the management of metastatic or advanced salivary gland cancers. Head Neck Oncol. 2012;4(1):19. doi: 10.1186/1758-3284-4-19. - DOI - PMC - PubMed
    1. Rodriguez T, Altieri A, Chatenoud L, Gallus S, Bosetti C, Negri E, Franceschi S, Levi F, Talamini R, Vecchia CL. Risk factors for oral and pharyngeal cancer in young adults. Oral Oncol. 2004;40:207–213. doi: 10.1016/j.oraloncology.2003.08.014. - DOI - PubMed

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