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Review
. 2012 Jun 20:7:70.
doi: 10.1186/1746-1596-7-70.

Primary intravascular large B-cell lymphoma of lung: a report of one case and review

Hui Yu  1 , Gang Chen, Rongxuan Zhang, Xiaolong Jin
Affiliations
Review

Primary intravascular large B-cell lymphoma of lung: a report of one case and review

Hui Yu et al. Diagn Pathol. .

Abstract

Objective: To investigate the clinicopathological features of primary intravascular large B-cell lymphoma of lung.

Methods: A case of primary pulmonary intravascular large B-cell lymphoma was analysed in histopathology and immunophenotype.

Results: The patient is a 42-year-old female who had cough for one year. Computed tomography showed ground-glass opacities and small nodules in bilateral lung fields. Histopathology demonstrated accumulation of similar sized neoplastic cells within alveolar capillaries, widening the alveolar septae. The alveolar structure sustained in part of districtions. Immunohistologically, the tumor cells were positive for CD20 and negative for CD3,CK, which were similar to the diffuse large B-cell lymphoma.

Conclusions: Intravascular large B-cell lymphoma is an uncommon type of non-Hodgkin's lymphoma. Primary pulmonary presentation is even more rare. The diagnosis is based on the histopathology and immunohistochemistry.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2076991810705433.

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Figures

Figure 1
Figure 1
chest CT-scan showed diffused interstitial shadows.
Figure 2
Figure 2
Hematoxylin-eosin staining of pulmonary interstitium intravascular lymphoma (100X).
Figure 3
Figure 3
Hematoxylin-eosin staining of pulmonary interstitium intravascular lymphoma (400X),the the alveolar septae was widen and filled with tumour cells showed in high power field.
Figure 4
Figure 4
CD20 immunostain of the neoplastic intravascular B lymphocytes (400X).
Figure 5
Figure 5
CD34 immunostain shows the neoplastic lymphocytes located in the alveolar capillaries,(200X).
Figure 6
Figure 6
KI-67 immunostain highlights the proliferation of intravascular lymphoma cells, (200X).
See this image and copyright information in PMC

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