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. 2012 Aug 7;10(29):5592-7.
doi: 10.1039/c2ob25727k. Epub 2012 Jun 20.

Iminosugar-ferrocene conjugates as potential anticancer agents

Audrey Hottin  1 , Faustine Dubar, Agata Steenackers, Philippe Delannoy, Christophe Biot, Jean-Bernard Behr
Affiliations

Iminosugar-ferrocene conjugates as potential anticancer agents

Audrey Hottin et al. Org Biomol Chem. .

Abstract

We prepared a series of new iminosugar-ferrocene hybrids displaying potent inhibition of fucosidase (bovine kidney) and inactivation of MDA-MB-231 breast cancer cells proliferation at low micromolar concentrations. The synthetic route brought to light an unprecedented isomerisation of a 2-ethanalylpyrrolidine.

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