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. 2012:2012:192503.
doi: 10.1155/2012/192503. Epub 2012 Jun 5.

Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?

Claus Desler  1 , Thomas Lau Hansen, Jane Bruun Frederiksen, Maiken Lise Marcker, Keshav K Singh, Lene Juel Rasmussen
Affiliations

Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?

Claus Desler et al. J Aging Res. 2012.

Abstract

Oxidative phosphorylation is an indispensable resource of ATP in tissues with high requirement of energy. If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue. The term reserve respiratory capacity or spare respiratory capacity is used to describe the amount of extra ATP that can be produced by oxidative phosphorylation in case of a sudden increase in energy demand. Depletion of the reserve respiratory capacity has been related to a range of pathologies affecting high energy requiring tissues. During aging of an organism, and as a result of mitochondrial dysfunctions, the efficiency of oxidative phosphorylation declines. Based on examples from the energy requiring tissues such as brain, heart, and skeletal muscle, we propose that the age-related decline of oxidative phosphorylation decreases the reserve respiratory capacity of the affected tissue, sensitizes the cells to surges in ATP demand, and increases the risk of resulting pathologies.

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References

    1. Sansbury BE, Jones SP, Riggs DW, Darley-Usmar VM, Hill BG. Bioenergetic function in cardiovascular cells: the importance of the reserve capacity and its biological regulation. Chemico-Biological Interactions. 2011;191(1-3):288–295. - PMC - PubMed
    1. Yadava N, Nicholls DG. Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone. Journal of Neuroscience. 2007;27(27):7310–7317. - PMC - PubMed
    1. Nicholls DG. Oxidative stress and energy crises in neuronal dysfunction. Annals of the New York Academy of Sciences. 2008;1147:53–60. - PubMed
    1. Hill BG, Higdon AN, Dranka BP, Darley-Usmar VM. Regulation of vascular smooth muscle cell bioenergetic function by protein glutathiolation. Biochimica et Biophysica Acta. 2010;1797(2):285–295. - PMC - PubMed
    1. Harman D. The biologic clock: the mitochondria? Journal of the American Geriatrics Society. 1972;20(4):145–147. - PubMed

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