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. 2012 Mar 1;1(2):255-257.
doi: 10.4161/onci.1.2.18345.

Immunotherapy: Is it different for sarcomas?

Anne-Marie Cleton-Jansen  1 , Emilie P Buddingh, Arjan C Lankester
Affiliations

Immunotherapy: Is it different for sarcomas?

Anne-Marie Cleton-Jansen et al. Oncoimmunology. .

Abstract

The Janus-faced roles of macrophages in cancer imply both tumor-suppressive and -stimulating actions of these innate immune cells. Whereas the balance is toward tumor promotion in most epithelial cancers, we have recently shown that osteosarcoma metastasis seems to be inhibited by macrophages. Here we discuss the possible mechanism of this observation.

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Figures

None
Figure 1. Osteosarcoma samples are infiltrated with CD14 and CD163 single and double positive macrophages. Spectral imaging was used to reduce autofluorescence of osteosarcoma cells. In the composite image, CD14-positive cells are represented in green, CD163-positive cells are represented in red, and CD14/CD163 double positive cells are represented in yellow. Background autofluorescence of tumor cells is represented in gray.
See this image and copyright information in PMC

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