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Review
. 2012 Nov;22(11):820-7.
doi: 10.1097/FPC.0b013e3283559b22.

Metformin pathways: pharmacokinetics and pharmacodynamics

Affiliations
Review

Metformin pathways: pharmacokinetics and pharmacodynamics

Li Gong et al. Pharmacogenet Genomics. 2012 Nov.
No abstract available

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Figures

Fig. 1
Fig. 1
Pharmacokinetics pathway of metformin. Stylized cells depicting genes involved in the transport and clearance of metformin. A fully interactive version is available online at http://www.pharmgkb.org/pathway/PA165948259. PD, pharmacodynamics.
Fig. 2
Fig. 2
Pharmacodynamics pathway of metformin. Stylized cells depicting the mechanism of action of metformin. A fully interactive version is available online at http://www.pharmgkb.org/pathway/PA165948566.

References

    1. Scarpello JH, Howlett HC. Metformin therapy and clinical uses. Diab Vasc Dis Res. 2008;5:157–167. - PubMed
    1. Viollet B, Guigas B, Sanz Garcia N, Leclerc J, Foretz M, Andreelli F. Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond) 2012;122:253–270. - PMC - PubMed
    1. DeFronzo RA, Goodman AM. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. N Engl J Med. 1995;333:541–549. - PubMed
    1. Reitman ML, Schadt EE. Pharmacogenetics of metformin response: a step in the path toward personalized medicine. J Clin Invest. 2007;117:1226–1229. - PMC - PubMed
    1. Hardie DG. AMP-activated protein kinase as a drug target. Annu Rev Pharmacol Toxicol. 2007;47:185–210. - PubMed

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