doi: 10.1038/embor.2012.91.
Epub 2012 Jun 22.
Elucidating the temporal order of silencing
Affiliations
- PMID: 22722480
- PMCID: PMC3410391
- DOI: 10.1038/embor.2012.91
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Elucidating the temporal order of silencing
EMBO Rep.
2012 Aug.
No abstract available
Conflict of interest statement
The author declares that she has no conflict of interest.
Figures
The GW182 proteins consist of an amino-terminal AGO-binding domain (ABD) and a silencing domain (SD) [2]. The silencing domain interacts with the cytoplasmic PABP and with the deadenylase complexes through multiple sequence motifs, which are represented as circles [2,9,10,11]. Two deadenylase complexes interact with GW182 proteins: the dimeric PAN2–PAN3 complex and the CCR4–NOT complex [2]. The mRNA is shown in a linear conformation with the translation factors eIF4E and eIF4G bound to the cap structure (m7G) and PABP bound to the poly(A) tail. In animal cell cultures, deadenylated mRNAs are decapped by the decapping enzyme DCP2 and further co-factors (not shown). Please refer to the text for more information. AGO, Argonaute; PABP, poly(A) binding protein.
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