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. 2012 Sep;26(9):1199-208.
doi: 10.1038/eye.2012.119. Epub 2012 Jun 22.

Incidence, presenting features, and diagnosis of cicatrising conjunctivitis in the United Kingdom

C F Radford  1 , S Rauz, G P Williams, V P J Saw, J K G Dart
Affiliations

Incidence, presenting features, and diagnosis of cicatrising conjunctivitis in the United Kingdom

C F Radford et al. Eye (Lond). 2012 Sep.

Abstract

Purpose: Cicatrising conjunctival disorders are uncommon, and are difficult to diagnose and manage. This study was designed to assess the annual incidence and underlying diagnosis of patients with cicatrising conjunctivitis (CC) within the United Kingdom.

Methods: Clinical data of newly diagnosed cases of CC were reported via the British Ophthalmological Surveillance Unit at diagnosis and at 12 months follow-up.

Results: A total of 50 (61%) ocular mucous membrane pemphigoid (OcMMP), 16 (20%) Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS-TEN) and 16 (20%) other causes of CC, equating to an incidence of 0.8, 0.2, and 0.2 per million, respectively, were reported. Although diagnosis of SJS-TEN was usually within a median of 7 days of symptom-onset, that for OcMMP and other CC was a median 225 days for both. At diagnosis, 64/163 (39%) eyes had moderate/severe conjunctival inflammation, and 102/164 (62%) had symblepharon formation. Although 43/82 (52%) patients were commenced on immunosuppression or had this therapy modified, at follow-up there was an increase in the number of symblepharon, despite control of inflammation (P<0.001). Mortality only occurred in the SJS-TEN group (4/16 (25%)).

Conclusion: CC has a substantial morbidity and for non-SJS-TEN causes, diagnosis is frequently delayed. The proportion of patients given immunosuppressive therapy to prevent disease progression may be less than optimal. These data highlight the need for developing patient access to specialist-designated centres with expertise in CC.

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Figures

Figure 1
Figure 1
Geographical distribution of newly reported cases of CC in the United Kingdom.
See this image and copyright information in PMC

References

    1. Williams GP, Radford C, Nightingale P, Dart JKG, Rauz S. Evaluation of early and late presentation of patients with ocular mucous membrane pemphigoid to two major tertiary referral hospitals in the United Kingdom. Eye. 2011;25 (9:1207–1218. - PMC - PubMed
    1. Chan LS, Ahmed AR, Anhalt GJ, Bernauer W, Cooper KD, Elder MJ, et al. The first international consensus of mucous membrane pemphigoid - Definition, diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators. Arch Dermatol. 2002;138:370–379. - PubMed
    1. Bernauer W, Itin PH, Kirtschig G.Cicatricial pemphigoidIn: Bernauer W, Dart JKG, Elder MJ (eds).Cicatrising Conjunctivitis. Developments in Ophthalmology Vol. 28Karger: Basel; 199746–63. - PubMed
    1. Bernauer W, Elder MJ, Dart JKG.Introduction to cicatrising conjunctivitisIn: Bernauer W, Dart JKG, Elder MJ (eds).Cicatrising Conjunctivitis. Developments in Ophthalmology Vol. 28Karger: Basel; 19971–10. - PubMed
    1. Bernard P, Vaillant L, Labeille B, Bedane C, Arbeille B, Denoeux JP, et al. Incidence and distribution of subepidermal autoimmune bullous skin diseases in three French regions. Arch Dermatol. 1995;131 (1:48–52. - PubMed

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