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Comment
. 2012 Jun 20;4(139):139fs20.
doi: 10.1126/scitranslmed.3004080.

Resurrecting DNAzymes as sequence-specific therapeutics

John J Rossi  1
Affiliations
Comment

Resurrecting DNAzymes as sequence-specific therapeutics

John J Rossi. Sci Transl Med. .

Abstract

In a mouse model of skin cancer, intratumoral injection of a sequence-specific mRNA-cleaving DNA enzyme caused potent inhibition of tumor growth and unusually benign pharmacodynamic profiles.

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Comment on

  • DNAzyme targeting c-jun suppresses skin cancer growth.
    Cai H, Santiago FS, Prado-Lourenco L, Wang B, Patrikakis M, Davenport MP, Maghzal GJ, Stocker R, Parish CR, Chong BH, Lieschke GJ, Wong TW, Chesterman CN, Francis DJ, Moloney FJ, Barnetson RS, Halliday GM, Khachigian LM. Cai H, et al. Sci Transl Med. 2012 Jun 20;4(139):139ra82. doi: 10.1126/scitranslmed.3003960. Sci Transl Med. 2012. PMID: 22723462

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