doi: 10.1016/0014-2999(90)90015-x.
Antagonism of 5-HT3 receptors attenuates the effects of ethanol on extracellular dopamine
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- PMID: 2272364
- DOI: 10.1016/0014-2999(90)90015-x
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Antagonism of 5-HT3 receptors attenuates the effects of ethanol on extracellular dopamine
Eur J Pharmacol.
.
Abstract
The effect of a 5-HT3 antagonist, ICS 205-930, on ethanol-induced changes in extracellular dopamine, was investigated with in vivo microdialysis. Pretreatment of rats with ICS 205-930 effectively attenuated the subsequent increases in dopamine, in both the nucleus accumbens and corpus striatum. This suggests that 5-HT may be involved in the effects of ethanol on dopaminergic systems.
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