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. 1990 Oct 9;187(2):287-9.
doi: 10.1016/0014-2999(90)90015-x.

Antagonism of 5-HT3 receptors attenuates the effects of ethanol on extracellular dopamine

K M Wozniak  1 , A Pert, M Linnoila
Affiliations

Antagonism of 5-HT3 receptors attenuates the effects of ethanol on extracellular dopamine

K M Wozniak et al. Eur J Pharmacol. .

Abstract

The effect of a 5-HT3 antagonist, ICS 205-930, on ethanol-induced changes in extracellular dopamine, was investigated with in vivo microdialysis. Pretreatment of rats with ICS 205-930 effectively attenuated the subsequent increases in dopamine, in both the nucleus accumbens and corpus striatum. This suggests that 5-HT may be involved in the effects of ethanol on dopaminergic systems.

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