Membrane protein structure predictions for exploration
- PMID: 22726429
- PMCID: PMC3688449
- DOI: 10.1016/j.cell.2012.06.004
Membrane protein structure predictions for exploration
Abstract
A daring experiment is performed. Using sequence alignments to predict contacts between residues in protein spatial structures, Hopf et al. are publishing untested de novo structure models for 11 transmembrane protein families. Will their models stand the test of time and hold up to experimentation? The prospects are excellent.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Three-dimensional structures of membrane proteins from genomic sequencing.Cell. 2012 Jun 22;149(7):1607-21. doi: 10.1016/j.cell.2012.04.012. Epub 2012 May 10. Cell. 2012. PMID: 22579045 Free PMC article.
References
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- Fodor AA, Aldrich RW. Proteins. 2004;56:211–221. - PubMed
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