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. 2012 Jun 22;149(7):1431-7.
doi: 10.1016/j.cell.2012.06.006.

A movie of RNA polymerase II transcription

Alan C M Cheung  1 , Patrick Cramer
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Free article

A movie of RNA polymerase II transcription

Alan C M Cheung et al. Cell. .
Free article

Abstract

We provide here a molecular movie that captures key aspects of RNA polymerase II initiation and elongation. To create the movie, we combined structural snapshots of the initiation-elongation transition and of elongation, including nucleotide addition, translocation, pausing, proofreading, backtracking, arrest, reactivation, and inhibition. The movie reveals open questions about the mechanism of transcription and provides a useful teaching tool.

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