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Case Reports
. 2012 Jun 23:4:38.
doi: 10.1186/1758-3284-4-38.

p16 overexpression in malignant and premalignant lesions of the oral and esophageal mucosa following allogeneic hematopoietic stem cell transplantation

Yasumasa Kakei  1 , Masaya Akashi, Hideki Komatsubara, Tsutomu Minamikawa, Takahide Komori
Affiliations
Case Reports

p16 overexpression in malignant and premalignant lesions of the oral and esophageal mucosa following allogeneic hematopoietic stem cell transplantation

Yasumasa Kakei et al. Head Neck Oncol. .

Expression of concern in

  • Comment: Head and Neck Oncology.
    BioMed Central. BioMed Central. BMC Med. 2014 Feb 5;12:24. doi: 10.1186/1741-7015-12-24. BMC Med. 2014. PMID: 24499430 Free PMC article. Review.

Abstract

Objectives: Secondary malignancy in the oral mucosa is recognized as one of the most serious complications in patients who received allogenic hematopoietic stem cell transplantation (HSCT). However, potential risk factors associated with carcinogenesis after HSCT that have been reported remain elusive. We experienced a rare case of secondary malignancies of the oral and esophageal mucosa and analyzed the expression of tumor suppressor gene product p16.

Case report: A 35-year-old male had malignant lesions of the oral and esophageal mucosa two years after HSCT. Partial maxillectomy and endoscopic submucosal dissection were performed. Immunohistochemical analyses revealed that the tumor cells of malignant and premalignant lesions of the oral cavity and esophagus but not keratosis were positive for p16.

Conclusions: Pathological examinations with p16 immunohistochemistry may contribute to an early diagnosis of secondary malignancy after HSCT.

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Figures

Figure 1
Figure 1
Erosive mass in the upper gingiva (A). White patches in the lower gingiva (B). Lesions unstained with lugol’s solution in the esophagus (C). Partial maxillectoy (D).
Figure 2
Figure 2
Immunohistochemical analyses for the expression of p16. Acanthosis (A, B), oral epithelial dysplasia (C, D) and oral squamous cell carcinoma (E, F) (H&E × 20) and (DAB peroxidase × 20). High grade intraepithelial neoplasia (G). The p16 positive control (lung adenocarcinoma) (H).
See this image and copyright information in PMC

References

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