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Review
. 2012 Aug;24(4):467-74.
doi: 10.1016/j.ceb.2012.05.009. Epub 2012 Jun 20.

Modular organization of the mammalian Golgi apparatus

Nobuhiro Nakamura  1 , Jen-Hsuan Wei, Joachim Seemann
Affiliations
Review

Modular organization of the mammalian Golgi apparatus

Nobuhiro Nakamura et al. Curr Opin Cell Biol. 2012 Aug.

Abstract

The Golgi apparatus is essential for post-translational modifications and sorting of proteins in the secretory pathway. In addition, it further performs a broad range of specialized functions. This functional diversity is achieved by combining basic morphological modules of cisternae into higher ordered structures. Linking cisternae into stacks that are further connected through tubules into a continuous Golgi ribbon greatly increases its efficiency and expands its repertoire of functions. During cell division, the different modules of the Golgi are inherited by different mechanisms to maintain its functional and morphological composition.

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Figures

Figure 1
Figure 1
Steps of the Golgi ribbon assembly. (a) Microtubules (red) derived from the Golgi (blue) gather stacks in the cell periphery, which are then moved along centrosome-organized microtubules to the perinuclear area of the cell. (b) Tethering proteins further bridge the clustered stacks. (c) and (d) In the final steps, homotypic cisternae of neighboring stacks are fused by tubular structures elongating on microtubules (red) and/or actin filaments (green) into a continuous ribbon.
See this image and copyright information in PMC

References

    1. Mellman I, Warren G. The road taken: past and future foundations of membrane traffic. Cell. 2000;100:99–112. - PubMed
    1. Geng J, Klionsky DJ. The Golgi as a potential membrane source for autophagy. Autophagy. 2010;6:950–951. - PMC - PubMed
    1. Guo Y, Chang C, Huang R, Liu B, Bao L, Liu W. AP1 is essential for generation of autophagosomes from trans-Golgi network. J Cell Sci. 2012 - PubMed
    1. Nakamura N. Emerging new roles of GM130, a cis-Golgi matrix protein, in higher order cell functions. J Pharmacol Sci. 2010;112:255–264. - PubMed
    1. Wilson C, Venditti R, Rega LR, Colanzi A, D'Angelo G, De Matteis MA. The Golgi apparatus: an organelle with multiple complex functions. Biochem J. 2011;433:1–9. - PubMed

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