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Comment
. 2012 Jun 21;74(6):961-3.
doi: 10.1016/j.neuron.2012.06.005.

DLK: the "preconditioning" signal for axon regeneration?

Paola Nix  1 , Michael Bastiani
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DLK: the "preconditioning" signal for axon regeneration?

Paola Nix et al. Neuron. .
Free article

Abstract

In this issue of Neuron, Shin et al. (2012) show that the dual leucine zipper kinase (DLK) is responsible for the retrograde injury signal in spinal sensory and motor neurons. DLK is required for the accelerated regeneration seen after axotomy and for the improved regeneration seen after a conditioning injury. DLK KO axons have severely reduced axon regeneration in vivo.

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