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. 2012 Jul;207(1):68.e1-9.
doi: 10.1016/j.ajog.2012.05.017. Epub 2012 May 23.

Prepregnancy cardiometabolic and inflammatory risk factors and subsequent risk of hypertensive disorders of pregnancy

Monique M Hedderson  1 , Jeanne A Darbinian, Sneha B Sridhar, Charles P Quesenberry
Affiliations

Prepregnancy cardiometabolic and inflammatory risk factors and subsequent risk of hypertensive disorders of pregnancy

Monique M Hedderson et al. Am J Obstet Gynecol. 2012 Jul.

Abstract

Objective: The purpose of this study was to examine prepregnancy cardiometabolic and inflammatory markers and the subsequent risk of hypertensive disorders of pregnancy.

Study design: This was a retrospective cohort study of 3380 women who took part in a comprehensive multiphasic health checkup (MHC) examination between 1984 and 1996 and who subsequently delivered at Kaiser Permanente Northern California.

Results: Two hundred five women were diagnosed with a hypertensive disorder of pregnancy. Prepregnancy measurements of overweight/obesity (body mass index, ≥25.0 kg/m(2)), prehypertension, and inflammation (leukocytes, ≥7.2 10(3)/μL) were associated independently with hypertensive disorder of pregnancy risk (odds ratio [OR], 1.6; 95% confidence interval [CI], 1.2-2.3; OR, 2.1; 95% CI, 1.5-2.8; and OR, 1.6; 95% CI, 1.1-2.3, respectively). Being overweight/obese and having prehypertension before pregnancy was associated with a 3.5-fold increased risk of hypertensive disorder of pregnancy compared with women with normal levels of both risk factors.

Conclusion: A prepregnancy cardiometabolic and inflammation risk profile may help clinicians identify high-risk women to target for early intervention or management of hypertensive disorder of pregnancy.

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Conflict of interest statement

Disclosure: ‘None of the authors have a conflict of interest.'

Figures

Figure 1
Figure 1
Odds ratios and 95% confidence intervals for hypertensive disorder of pregnancy associated with number of prepregnancy cardiometabolic and inflammatory risk factors.
Figure 2
Figure 2
Odds ratios and 95% confidence intervals for hypertensive disorder of pregnancy associated with prepregnancy body mass index and blood pressure levels.
See this image and copyright information in PMC

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