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Review
. 2012 Sep;64(12):1063-77.
doi: 10.1016/j.addr.2012.06.008. Epub 2012 Jun 21.

Demineralized bone matrix in bone repair: history and use

Elliott Gruskin  1 , Bruce A Doll, F William Futrell, John P Schmitz, Jeffrey O Hollinger
Affiliations
Review

Demineralized bone matrix in bone repair: history and use

Elliott Gruskin et al. Adv Drug Deliv Rev. 2012 Sep.

Abstract

Demineralized bone matrix (DBM) is an osteoconductive and osteoinductive commercial biomaterial and approved medical device used in bone defects with a long track record of clinical use in diverse forms. True to its name and as an acid-extracted organic matrix from human bone sources, DBM retains much of the proteinaceous components native to bone, with small amounts of calcium-based solids, inorganic phosphates and some trace cell debris. Many of DBM's proteinaceous components (e.g., growth factors) are known to be potent osteogenic agents. Commercially sourced as putty, paste, sheets and flexible pieces, DBM provides a degradable matrix facilitating endogenous release of these compounds to the bone wound sites where it is surgically placed to fill bone defects, inducing new bone formation and accelerating healing. Given DBM's long clinical track record and commercial accessibility in standard forms and sources, opportunities to further develop and validate DBM as a versatile bone biomaterial in orthopedic repair and regenerative medicine contexts are attractive.

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Figures

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Graphical abstract
Fig. 1
Fig. 1
DBM publications by year based on PubMed search (through 2010).
See this image and copyright information in PMC

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