Novel antinematodal and antiparasitic agents from Penicillium charlesii. I. Fermentation, isolation and biological activity
- PMID: 2272914
- DOI: 10.7164/antibiotics.43.1375
Novel antinematodal and antiparasitic agents from Penicillium charlesii. I. Fermentation, isolation and biological activity
Abstract
Paraherquamide and six novel analogs were isolated from the fermentation of Penicillium charlesii (ATCC 20841). All seven natural products displayed potent antinematodal activity against Caenorhabditis elegans. None of the novel analogs were more potent than paraherquamide.
Similar articles
-
Further novel metabolites of the paraherquamide family.J Antibiot (Tokyo). 1993 Sep;46(9):1355-63. doi: 10.7164/antibiotics.46.1355. J Antibiot (Tokyo). 1993. PMID: 8226314
-
New paraherquamide antibiotics with anthelmintic activity.J Antibiot (Tokyo). 1991 May;44(5):492-7. doi: 10.7164/antibiotics.44.492. J Antibiot (Tokyo). 1991. PMID: 2061192 No abstract available.
-
[3H]paraherquamide binding to Caenorhabditis elegans. Studies on a potent new anthelmintic agent.Biochem Pharmacol. 1992 Feb 18;43(4):679-84. doi: 10.1016/0006-2952(92)90230-g. Biochem Pharmacol. 1992. PMID: 1540222
-
Marcfortine and paraherquamide class of anthelmintics: discovery of PNU-141962.Curr Top Med Chem. 2002 Jul;2(7):779-93. doi: 10.2174/1568026023393705. Curr Top Med Chem. 2002. PMID: 12052190 Review.
-
Anthelmintic drugs and nematicides: studies in Caenorhabditis elegans.WormBook. 2014 Dec 16:1-29. doi: 10.1895/wormbook.1.143.2. WormBook. 2014. PMID: 25517625 Free PMC article. Review.
Cited by
-
Isolation and insecticidal activity of mellamide from Aspergillus melleus.J Ind Microbiol Biotechnol. 2003 Apr;30(4):220-4. doi: 10.1007/s10295-003-0048-y. Epub 2003 Apr 8. J Ind Microbiol Biotechnol. 2003. PMID: 12687496
-
Structural and stereochemical diversity in prenylated indole alkaloids containing the bicyclo[2.2.2]diazaoctane ring system from marine and terrestrial fungi.Nat Prod Rep. 2018 Jun 20;35(6):532-558. doi: 10.1039/c7np00042a. Nat Prod Rep. 2018. PMID: 29632911 Free PMC article. Review.
-
Flavin-Dependent Monooxygenases NotI and NotI' Mediate Spiro-Oxindole Formation in Biosynthesis of the Notoamides.Chembiochem. 2020 Sep 1;21(17):2449-2454. doi: 10.1002/cbic.202000004. Epub 2020 May 14. Chembiochem. 2020. PMID: 32246875 Free PMC article.
-
Studies on Paraherquamide Biosynthesis: Synthesis of Deuterium-Labeled 7-Hydroxy-Pre-Paraherquamide, a Putative Precursor of Paraherquamides A, E & F.Tetrahedron. 2009 Apr 18;65(16):3246-3260. doi: 10.1016/j.tet.2008.08.102. Tetrahedron. 2009. PMID: 20161298 Free PMC article.
-
Concise, Biomimetic Total Synthesis of d,l-Marcfortine C.Tetrahedron. 2007 Jul 2;63(27):6124-6130. doi: 10.1016/j.tet.2007.03.016. Tetrahedron. 2007. PMID: 18596842 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources