Boosting antibody therapy with complement
- PMID: 22730521
- DOI: 10.1182/blood-2012-04-420760
Boosting antibody therapy with complement
Abstract
In this issue of Blood, Elvington et al present a method to enhance complement activation during antibody therapy of cancer. Using a fusion protein of a complement receptor and an IgG Fc fragment, therapeutic outcome was improved in vivo.
Comment on
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A targeted complement-dependent strategy to improve the outcome of mAb therapy, and characterization in a murine model of metastatic cancer.Blood. 2012 Jun 21;119(25):6043-51. doi: 10.1182/blood-2011-10-383232. Epub 2012 Mar 22. Blood. 2012. PMID: 22442351 Free PMC article.
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